Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire and the doctors are introduced to a few new faces that spice things up around the hospital.

Meredith struggles to come up with a new plan for Owen's sister. Jo makes a surprising choice regarding Alex. Andrew's sister's controversial research leads to a shocking discovery.