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In Grey's Anatomy, the characters coin certain important words that are often used in their dialogue with the prefix "Mc".

Season 1
  • McBird - The first of the trend used by another intern to describe the patient that George is performing on. (Episode 1: A Hard Day's Night)
  • McDreamy - The nickname given to Derek Shepherd by Cristina Yang. (Episode 2: The First Cut is the Deepest)
Season 2
  • McMarried - Used by George O'Malley to describe Derek Shepherd's marital status. (Episode 1: Raindrops Keep Falling On My Head)
  • McWhat - said by Izzie after she found out that Derek was married. (Episode 1: Raindrops Keep Falling On My Head)
  • McBastard - a reference to Derek after Meredith found out that he was married (Episode 1: Raindrops Keep Falling On My Head)
  • McDouchey - Christina describing Derek Shepherd for not allowing her to scrub in on his surgery. (Episode 14: Tell Me Sweet Little Lies)
  • McDog - The dog shared by Derek and Meredith named Doc. (Episode 16: It's the End of the World)
  • McLife - the term used by Meredith to describe Addison Montgomery-Shepherd's influence over her life. Addison has Derek and now her dog. (Episode 16: It's the End of the World)
  • McSexy - a suggestion for a nickname for Mark Sloan when he first arrived to Seattle Grace. (Episode 18: Yesterday)
  • McYummy - another suggestion for a nickname for Mark Sloan. (Episode 18: Yesterday)
  • McSteamy - the nickname that Izzy, Meredith and Christina agreed for Mark Sloan. (Episode 18: Yesterday)
  • McVomit - the term for George's disgust of the new nickname for Mark Sloan.(Episode 18: Yesterday)
  • McHot - used by Alex Karev to describe Addison Montgomery-Shepherd.(Episode 18: Yesterday)
  • McYeah - George's assertion with the term used to describe Addison. (Episode 18: Yesterday)
  • McDreamy - In this case, Izzy uses this nickname to describe George being the centre of Callie's attraction. (Episode 22: Name of the Game)
  • McVet - given to veterinarian Finn Dandridge. (Episode 23: Blues for Sister Someone)

Season 3
  • McGuilty - what Cristina calls Derek following his extramarital sex with Meredith at the prom that is being hosted in the hospital. (Episode 1: Time Has Come Today)
  • McBaby - what Cristina calls Meredith’s suspected pregnancy. (Episode 4: What I Am)
  • McNasty - George describing what Derek had allegedly done with the woman in his trailer. Unbeknownst to them, the woman was Derek's sister, Nancy. (Episode 6: Let the Angels Commit)
  • McHottie - George's term for Derek's sister, Nancy. (Episode 6: Let the Angels Commit)
  • McBastard - George labelling Derek, assuming that he was going to have intercourse with the woman in his trailer.(Episode 6: Let the Angels Commit)
  • McSister - given to Derek's sister, Nancy. (Episode 6: Let the Angels Commit)
  • McBitchy - Izzie refers to Derek’s sister, Nancy, after she insinuates that Meredith is the reason for the Shepherds’ divorce. (Episode 6: Let the Angels Commit)
  • McSex - Callie’s reference to catching Meredith and Derek having sex at the prom.(Episode 9: From a Whisper to a Scream)
  • McLove Life - Christina's reference to Meredith's relationships (Episode 16: Drowning on Dry Land)
  • McCrap - Christina describing Meredith's problems.(Episode 16: Drowning on Dry Land)
  • McFrickin' Code of Silence! Callie describing when she claimed Meredith's panties off the wall (Episode 19: From a Whisper to a Scream)